NCT02240056

Brain fMRT In Takotsubo Cardiomyopathy

Pilot Study: Central Nervous System and Hormonal Changes In Takotsubo Cardiomyopathy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 55 (actual)
• Sponsor: Wolfgang Dichtl, MD PhD · Academic / Other
• Sex: Female
• Age: 90 Years
• Healthy volunteers: Not accepted

Summary

Certain cardiac and neurologic diseases influence each other via a still poorly understood "brain-heart axis". Subarachnoidal bleedings are well known to cause ECG alterations resembling those of myocardial infarction, along with a reduction of systolic myocardial function ("neurogenic stunned myocardium"). Alterations of the right insula region by a stroke or intracranial hemorrhage go along with a sympathetic activation (increased circulating catecholamine levels, tachycardia, arterial hypertension). In contrast, alterations of the left insula region often cause vagal reactions such as bradycardia, arterial hypotension. Takotsubo cardiomyopathy (TTC) is a just recently recognised subform of heart attacks, often caused by psychological or physical stress (death of a beloved one, divorce, job loss, infection, preoperative state). In more than 90% of cases, TTC affects postmenopausal women. Functional MRT enables imaging of activated brain regions, either without ("resting state") or with specific stimuli. The investigators speculate that there is a specific involvement of the insula region during TTC.

Conditions

• Takotsubo Cardiomyopathy

Timeline

• Start date: 2014-10-01
• Primary completion: 2018-12-01
• Completion: 2019-03-01
• First posted: 2014-09-15
• Last updated: 2019-03-07

Locations

1 site across 1 country: Austria