NCT02237053

Effects of Glucagon Administration on Energy Expenditure

A Prospective Randomized, Placebo (Saline)-Controlled, Balanced, 3-treatment Regimen Crossover Study Comparing the Effects of Prolonged (13 h) Hyperglucagonemia With Those of Acute (3 hr) Hyperglucagonemia on Energy Expenditure and Endogenous Glucose Protection (EGP).

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 6 (actual)
• Sponsor: AdventHealth Translational Research Institute · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to collect data to help researchers better understand the effects of glucagon on the amount of calories burned.

Detailed description

1. To compare the effect of prolonged hyperglucagonemia to that of acute hyperglucagonemia on energy expenditure in healthy subjects using room indirect calorimetry in the setting of octreotide-mediated prevention of plasma insulin excursions. 2. To compare the effects of prolonged hyperglucagonemia to acute hyperglucagonemia on EGP in healthy subjects in the setting of octreotide-mediated prevention of plasma insulin excursions. 3. To determine the effects of prolonged hyperglucagonemia to acute hyperglucagonemia on rates of substrate oxidation, fibroblast growth factor21 and metabolites of interest.

Conditions

• Hyperglucagonemia
• Obesity

Interventions

Type	Name	Description
DRUG	Glucagon
DRUG	Octreotide
BEHAVIORAL	Placebo
DRUG	Insulin

Timeline

• Start date: 2014-09-01
• Primary completion: 2015-06-01
• Completion: 2016-06-01
• First posted: 2014-09-11
• Last updated: 2018-04-26

Locations

1 site across 1 country: United States