NCT02232789

Abuse Liability and Human Pharmacology of Mephedrone

Abuse Liability and Human Pharmacology of Mephedrone (4-methylmethcathinone,4-MMC)

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Parc de Salut Mar · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purposes of this study are 1) to evaluate the abuse liability and human pharmacology of mephedrone after oral administration and 2) to compare the pharmacological effects of mephedrone with those obtained after administration of oral 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).

Detailed description

Mephedrone is a new psychoactive substance (NPS). At present, there are no randomized controlled trials evaluating the effects of mephedrone in humans. The current body of knowledge regarding the acute effects of mephedrone is based on anecdotal, self-reported effects (e.g. internet forums), case reports, and emergency room series and fatalities. The aims of this study are 1) to evaluate the abuse liability and human pharmacology of mephedrone after oral administration and 2) to compare the pharmacological effects of mephedrone with those obtained after administration of oral 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).

Conditions

• Amphetamine-Related Disorders

Interventions

Type	Name	Description
DRUG	Mephedrone	Single oral dose mephedrone
DRUG	3,4-methylenedioxymethamphetamine	Single oral dose MDMA
DRUG	Placebo	Single oal dose placebo

Timeline

• Start date: 2014-09-01
• Primary completion: 2014-12-01
• Completion: 2014-12-01
• First posted: 2014-09-05
• Last updated: 2014-12-04

Locations

1 site across 1 country: Spain