NCT02229032

Genetic Analysis Between Charlotte's Web Responders Versus Non- Responders in a Dravet Population

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 19 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

There is tremendous curiosity about medical marijuana and the treatment of epilepsy. In a specific genetic epilepsy known as Dravet Syndrome, a mutation occurs affecting the SCN1A gene. A specific strain of marijuana known as Charlotte's Web, available in Colorado, may have activity in this catastrophic epilepsy syndrome. Anecdotal reports suggest both success and lack of response with this therapy. Genetic analysis of the differences between Dravet responders and non-responders may prove useful for identifying patients likely to be helped by this therapy, as well as shed light on the putative mechanisms by which marijuana may exert any antiepileptic effect.

Conditions

• Dravet Syndrome

Timeline

• Start date: 2014-08-01
• Primary completion: 2017-07-01
• Completion: 2017-07-01
• First posted: 2014-08-29
• Last updated: 2017-12-15

Locations

1 site across 1 country: United States