NCT02222844

Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 244 (estimated)
• Sponsor: Imperial College London · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

Patients with suspected or proven sigmoid colon adenocarcinoma, eligible for curative treatment whose MRI can be reviewed prior to surgery and has no decision regarding radical treatment are eligible. Patient are randomised to the control arm which the standard care of preoperative CT imaging and subsequent discussion by the Multidisciplinary Team or the interventional arm which has the additional use of MRI imaging and subsequent discussion by the Multidisciplinary Team. Patients are followed up at 1 and 3 years together with QoL questionnaires.

Detailed description

A randomised phase II multicentre trial, IMPRESS will determine whether the use of MRI imaging in staging sigmoid cancers results in a change to the treatment plan by identifying more high risk tumours compared to those patients who were staged using CT imaging. The proposed intervention will be additional radiological and pathological assessment and the reporting of supplementary diagnostic information which would not otherwise have been available. This may affect treatment according to local MDT protocols and also affect the provision of prognostic information to patients in subsequent discussions.

Conditions

• Cancer
• Colorectal Neoplasms
• Colon, Sigmoid
• Magnetic Resonance Imaging
• General Surgery

Interventions

Type	Name	Description
OTHER	Preoperative MRI scan	Standard preoperative CT of abdomen, chest and pelvis plus interventional preoperative MRI scan.

Timeline

• Start date: 2014-08-01
• Primary completion: 2026-12-01
• Completion: 2031-12-01
• First posted: 2014-08-21
• Last updated: 2024-10-17

Locations

16 sites across 1 country: United Kingdom