Trials / Completed
CompletedNCT02222142
Volatile Versus Propofol Anesthesia in OPCAB
Comparison of Propofol and Isoflurane Anesthesia on Cardioprotection and Clinical Outcomes in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery : A Propensity-score Analysis
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 1,080 (actual)
- Sponsor
- Samsung Medical Center · Academic / Other
- Sex
- All
- Age
- 20 Years
- Healthy volunteers
- Not accepted
Summary
Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode. The investigators retrospectively evaluated the cardioprotective and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB.
Detailed description
Several experimental and clinical researches have suggested that volatile anesthetics may reduce mortality in cardiac surgery owing to its preconditioning induced cardioprotective effect. Off-pump coronary artery bypass graft (OPCAB) surgery still requires cardioprotective strategies due to coronary hypoperfusion during anastomosis. The aim of this study was to evaluate the possible cardioprotective effect and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB using propensity matching.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Isoflurane | Comparison between isoflurane and propofol, Retrospective study |
Timeline
- Start date
- 2010-01-01
- Primary completion
- 2012-12-01
- Completion
- 2012-12-01
- First posted
- 2014-08-21
- Last updated
- 2014-08-21
Locations
1 site across 1 country: South Korea
Source: ClinicalTrials.gov record NCT02222142. Inclusion in this directory is not an endorsement.