Trials / Terminated
TerminatedNCT02221505
Phase 1 Study of LOP628 in Adult Patients With cKit-positive Solid Tumors and Acute Myeloid Leukemia
A Phase I, Multicenter, Open-label Dose Escalation and Expansion Study of LOP628, Administered Intravenously in Adult Patients With cKit-positive Tumors and Acute Myeloid Leukemia
- Status
- Terminated
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 3 (actual)
- Sponsor
- Novartis Pharmaceuticals · Industry
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
LOP628 is an antibody-drug conjugate (ADC) consisting of an anti-cKit humanized IgG1/κ antibody conjugated to a maytansine payload via a non-cleavable linker. LOP628 provides an opportunity to target cKit overexpressing tumors.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | LOP628 |
Timeline
- Start date
- 2014-12-01
- Primary completion
- 2015-03-01
- Completion
- 2015-03-01
- First posted
- 2014-08-20
- Last updated
- 2016-04-05
Locations
4 sites across 4 countries: Australia, Belgium, Netherlands, Spain
Source: ClinicalTrials.gov record NCT02221505. Inclusion in this directory is not an endorsement.