NCT02221050

Hemodialysis and Wanting for Protein-rich Foods

Influence of Chronic Renal Failure and Hemodialysis on Liking and Wanting for Foods

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 48 (actual)
• Sponsor: University of Burgundy · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

A study conducted in the laboratory revealed the existence of a "window" during which patients with renal failure appreciate the protein-rich foods. This period, located immediately after the dialysis, is likely related to the purification of plasma products resulting from protein catabolism. It therefore appears necessary to understand the mechanisms that may explain these changes by measurements of ghrelin (orexigenic hormone), leptin (anorectic hormone) and plasma amino acids.

Detailed description

In 24 patients with renal failure treated by hemodialysis, it is evaluated (at 8:00 am and at 11:00 am), a day without hemodialysis and another day after the hemodialysis: * Hunger sensation, * Olfactory liking assessed separately for 6 foods (2 carbohydrate-, 2 fat- and 2 protein-rich foods) and 2 non-alimentary products, * Food wanting evaluated by the sequential presentation of 18 images of food (6 fat-, 6 carbohydrate- and 6 protein-rich foods), * Two blood samples for the assays of leptin, ghrelin, creatinine, albumin and pre-albumin as well as plasma amino acids. 24 healthy subjects are also evaluated in order to compare the results from patients to those of control subjects.

Conditions

• Renal Failure

Timeline

• Start date: 2014-01-01
• Primary completion: 2014-05-01
• Completion: 2014-07-01
• First posted: 2014-08-20
• Last updated: 2014-08-20

Locations

1 site across 1 country: France