NCT02220400

Ketamine Prevent POCD

Low Dose Ketamine Prevent the Postoperative Cognitive Dysfunction in Aged Patients Underwent Orthopaedic Surgery，a Randomized Control Double Blinded Multicenter Clinical Trail

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 484 (estimated)
• Sponsor: RenJi Hospital · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inflammation agent. In present study investigators hypothesized that low dose ketamine would prevent the cognition decline after orthopedic surgery in aged patients.

Conditions

• Necrosis of Femoral Head
• Knee Osteoarthritis

Interventions

Type	Name	Description
DRUG	Ketamine

Timeline

• Start date: 2014-09-01
• Primary completion: 2016-09-01
• Completion: 2016-09-01
• First posted: 2014-08-19
• Last updated: 2014-08-19

Locations

3 sites across 1 country: China