NCT02217683

Use of Inhaled Nitric Oxide to Prevent Pulmonary Hypertension Associated to Stored Blood Transfusion

Pulmonary Hemodynamic Effects of Stored Red Blood Cell Transfusion in Post-Operative Cardiac Surgical Patients: Influence of Breathing Nitric Oxide. A Randomized Controlled Trial in the Cardiac-Intensive Care Unit.

• Status: Withdrawn
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The objective of this study is to assess if prolonged storage time of a packed red blood cell unit may cause pulmonary vasoconstriction after transfusion, in a susceptible population such as cardiac surgery patients. The investigators will also evaluate the potential reversal effect of Inhaled Nitric Oxide on pulmonary vasoconstriction induced by stored blood transfusions.

Detailed description

Patients will be randomized into one of the three groups: I. Blood transfusion stored for less than 10 days II. Blood transfusion stored for more than 30 days III. Blood transfusion stored for more than 30 days days plus inhalation of Nitric Oxide at 80 part per million for an hour during blood transfusion.

Conditions

• Hypertension, Pulmonary
• Hemolysis

Interventions

Type	Name	Description
DRUG	Nitric Oxide	Nitric oxide at 80 part per million will be administrated by inhalation for approximately 1 hour during the blood transfusion

Timeline

• Start date: 2016-03-01
• Primary completion: 2016-12-01
• Completion: 2017-04-01
• First posted: 2014-08-15
• Last updated: 2016-03-18

Locations

1 site across 1 country: United States