NCT02217319

Cardioprotection by Sevoflurane Preconditioning in Noncardiac Thoracic Surgery

Does a Sevoflurane Preconditioning Have Cardioprotective Properties in Noncardiac Thoracic Surgery?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Dr. Horst Schmidt Klinik GmbH · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

It has been shown that the use of volatile anaesthetics, that are usually used to perform a general anesthesia, have cardioprotective properties. This has been shown in animal studies and in patients that underwent cardiac surgery. The aim of our study is to examine if Sevoflurane, a volatile anaesthetic, has this properties in patients undergoing lung surgery.

Conditions

• High Sensitive Troponin T Release

Interventions

Type	Name	Description
DRUG	Sevoflurane	Anaesthesia is induced (1-2 mg/kg) and maintained (5-7 mg/kg/h) with propofol and remifentanil (1 µg/kg and 0,2-0,4 µg/kg/min). After induction of anesthesia the propofol infusion is stopped and patients receive 1 MAC Sevoflurane over 30 min. Then the propofol infusion is restarted and Sevoflurane is washed out.
DRUG	TIVA	Anaesthesia is induced (1-2 mg/kg) and maintained (5-7 mg/kg/h) with propofol and remifentanil (1 µg/kg and 0,2-0,4 µg/kg/min).

Timeline

• Start date: 2012-09-01
• Primary completion: 2013-08-01
• Completion: 2013-09-01
• First posted: 2014-08-15
• Last updated: 2016-08-03

Locations

1 site across 1 country: Germany