NCT02213588

Effects of Plant Concentrate Blend on Oxidative Stress in Healthy Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Access Business Group · Industry
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the response to oxidative stress in healthy men and women after taking a blend of plant concentrate.

Detailed description

The purpose of this study is to evaluate how blends of plant concentrates impacts oxidative stress in humans. Biomarkers of oxidative stress will be measured at three time points in 3 month intervention. Based on our proof of concept dose response study, it was shown that the plant concentrate at the proposed dose can lower markers of oxidative damage and induce the production of antioxidant enzymes. We would like to confirm these findings and further evaluate the implication of increased antioxidative enzymes as seeing in our proof of concept study. An acute oxidative stress will be induced by a high glycemic drink and short aerobic exercise and the response during the induction of an acute oxidative stress as well as the recovery from an acute oxidative stress. Since the induction of antioxidative enzymes not only is linked to the protection of proteins and lipids from oxidative damage, it is also linked to the protection of DNA damage. Therefore, in this study, comet assay will be performed to evaluate the integrity of DNA.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	AOX blend	Antioxidant supplement
DIETARY_SUPPLEMENT	Placebo

Timeline

• Start date: 2013-07-01
• Primary completion: 2013-12-01
• Completion: 2014-08-01
• First posted: 2014-08-11
• Last updated: 2014-08-11

Locations

1 site across 1 country: United States