NCT02208505

Antitussive Effect of Single-dose Dexmedetomidine With Low-dose Remifentanil Infusion

Antitussive Effect of Single-dose Dexmedetomidine With Low-dose Remifentanil Infusion During Emergence in Adults After Thyroidectomy: Comparison With High-dose Remifentanil Infusion Alone

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 168 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

After thyroid surgery, the incidence and severity of coughing is important because it may cause serious complications, such as bleeding in the surgical field, laryngospasm, and cardiovascular disturbance. Several studies have shown that the single-dose of dexmedetomidine is effective for reducing cough and agitation during emergence from general anesthesia. To test the hypothesis that single-dose of dexmedetomidine combined with a low-dose remifentanil infusion during emergence from general anaesthesia could reduce coughing as good as high-dose remifentanil infusion, we will evaluate the efficacy on cough suppression and reduction of side effect of remifentanil using non-inferiority trial.

Conditions

• Thyroidectomy

Interventions

Type	Name	Description
DRUG	Dexmedetomidine + Remifentanil-low dose	single dose administration (0.5mcg/kg) 10 min before end of the surgery with maintain the infusion of remifentanil (TCI 1 ng/ml) until end of surgery
DRUG	Remifentanil-high dose	maintain the infusion of remifentanil until end of the surgery (TCI 2 ng/ml)

Timeline

• Start date: 2014-02-01
• Primary completion: 2015-07-01
• Completion: 2015-12-01
• First posted: 2014-08-05
• Last updated: 2017-10-18

Locations

1 site across 1 country: South Korea