NCT02208466

Effects rTMS Combined With Fluoxetine on Motor Recovery in Stroke Patients

Effects of Contralesional Repetitive Magnetic Stimulation Combined With Fluoxetine on Motor Recovery in Acute Stroke Patients

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: Spaulding Rehabilitation Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In this study investigator's aim to assess the effect of a type of non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) in conjunction with fluoxetine on motor recovery after stroke.

Conditions

• Stroke
• Motor Function

Interventions

Type	Name	Description
DEVICE	Active Repetitive Transcranial Magnetic Stimulation (rTMS)	Subjects will undergo active low-frequency rTMS (1Hz continuous). Each session will last 20 minutes and will be conducted at 100% of the motor threshold.
DRUG	Fluoxetine	Subjects will receive active fluoxetine (20mg) and take orally consecutively for 90 days.
DEVICE	Sham repetitive transcranial magnetic stimulation (rTMS)	Subjects will undergo sham low-frequency rTMS (using sham coil). This session will last 20 minutes, just as the active session would, however, no magnetic pulses will be delivered.
DRUG	Placebo Fluoxetine	Subject will receive placebo fluoxetine (sugar pills) and will take orally consecutively for 90 days.

Timeline

• Start date: 2014-09-01
• Primary completion: 2019-06-25
• Completion: 2019-06-25
• First posted: 2014-08-05
• Last updated: 2021-02-21
• Results posted: 2021-02-21

Locations

1 site across 1 country: United States