NCT02206841

Establishment of NAFLD Cohort and Development of Fibrosis Markers

Establishment of Non-alcoholic Fatty Liver Disease Cohort and Development of Markers to Predict Histologic Progression of Liver Fibrosis

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,000 (estimated)
• Sponsor: Seoul National University Boramae Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is designed for establishment of non-alcoholic fatty liver disease patients cohort to development of markers to predict histologic progression of liver fibrosis.

Detailed description

* Acoustic radiation force impulse elastography and transient elastography * Liver tissue (frozen tissue, paraffin block) * Whole blood, Serum * Fat amount ratio CT (Visceral adipose tissue, Subcutaneous adipose tissue amount) * Body composition analyzer (InBody scale):Total fat/muscle mass and appendicular skeletal muscle mass * Pulmonary function test with post-bronchodilator response and DLCo * EKG, EchoCG, Heart CT (Coronary calcium score), and Pusle wave velocity (AI index, arterial stiffness) * Brain MRI or CT * Upper esophagogastroscopy and colonoscopy * Berlin score questionnaire and Polysomnography

Conditions

• Fibrosis of Liver

Interventions

Type	Name	Description
PROCEDURE	Liver biopsy	Percutaneously liver biopsy will be performed for evaluate steatosis and fibrosis.
DEVICE	ARFI	Acoustic radiation force impulse (ARFI) imaging will be performed for evaluate fibrosis of liver.
DEVICE	SWE	Supersonic shear wave elastography (SWE) will be performed for evaluate fibrosis of liver.
DEVICE	Transient elastography	Transient elastography will be performed for evaluate fibrosis of liver.

Timeline

• Start date: 2014-01-01
• Primary completion: 2029-12-31
• Completion: 2030-12-31
• First posted: 2014-08-01
• Last updated: 2025-05-15

Locations

1 site across 1 country: South Korea