NCT02205983

The Effects of Hydromorphone on Responses to Verbal Tasks

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: University of Chicago · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

In this study, the investigators will examine the effects of hydromorphone, as compared to placebo, upon physiological, subjective, and hormonal responses to a stressful speech task and a non-stressful control task in healthy adults. There is strong evidence in support of the role of endogenous opioids and opiates in mediating social behavior in humans and other animals, and particularly, in social distress. The investigators have recently shown that buprenorphine, a partial mu-opioid agonist, reduces cortisol responses to stress. Here, the investigators propose to further explore the role of the opioid system in mediating stress responses in humans through the use of hydromorphone, a full mu opioid agonist, in addition to acetaminophen. The investigators hypothesize that like acetaminophen, hydromorphone will reduce both physiological and subjective measures of stress.

Detailed description

Participants be randomly assigned to receive 1000 mg acetaminophen, 2mg hydromorphone, 4mg hydromorphone, or placebo at each of two sessions; one during which they well participate in a stressful speaking task, and one during which they'll participate in a nonstressful control task. Physiological and subjective measures will be taken throughout each session.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	2 mg hydromorphone	We are administering oral hydromorphone to healthy volunteers to measure its effects on the performance of a verbal task.
DRUG	1000 mg Acetaminophen	We are administering sublingual buprenorphine to healthy volunteers to measure its effects on the performance of a verbal task.
DRUG	4 mg hydromorphone	We are administering oral hydromorphone to healthy volunteers to measure its effects on the performance of a verbal task.
DRUG	dextrose	We are administering dextrose to healthy volunteers for our placebo group.

Timeline

• Start date: 2015-01-01
• Primary completion: 2016-07-01
• Completion: 2016-09-01
• First posted: 2014-08-01
• Last updated: 2018-10-09
• Results posted: 2018-10-09

Locations

1 site across 1 country: United States