NCT02202239

Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Zhujiang Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

To explore the effect of induction and maintenance of anesthesia with etomidate on hemodynamics and oxidative stress in diabetic patients.

Conditions

• Hemodynamics
• Oxidative Stress
• Anesthesia

Interventions

Type	Name	Description
DRUG	midazolam	Before induction, midazolam 0.05mg/kg will be injected intravenously.
DRUG	Penehyclidine Hydrochloride Injection	Penehyclidine Hydrochloride 0.01mg/kg will be injected intravenously after midazolam is injected.
DRUG	Etomidate	Induction dose: 0.3 mg/kg. Maintenance dose: 10 μg•kg-1•min-1.
DRUG	Propofol	Induction dose: 2.0 mg/kg. Maintenance dose: 4 to 6 mg/kg/h.
DRUG	Fentanyl	During induction, after injection of etomidate, fentanyl 3 μg/kg will be given intravenously.
DRUG	Cisatracurium Besilate	Cisatracurium Besilate 0.14 mg/kg will be used after fentanyl is injected for induction. During maintenance, intermittent bolus of cisatracurium will be used for maintain muscle relaxation.
DRUG	Remifentanil	Remifentanil will be injected continuously during maintenance of anesthesia.
DRUG	Sevoflurane	Sevoflurane of 1% to 2% will be administered via inhalation to keep bispectral index（BIS) between 50 to 55.

Timeline

• Start date: 2014-09-01
• Primary completion: 2015-08-01
• Completion: 2015-08-01
• First posted: 2014-07-28
• Last updated: 2014-07-28