NCT02199912

Study of the Relationship Between Clinical and Paraclinical Markers During Situations of Cachexia and Pre-cachexia in Patients Over 70 Years With Colorectal Surgery

ANC2 Pilot Study Study of the Relationship Between Clinical and Paraclinical Markers During Situations of Cachexia and Pre-cachexia in Patients Over 70 Years With Colorectal Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 59 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 70 Years
• Healthy volunteers: Not accepted

Summary

Cachexia associated with cancer is a grave and most of the time irreversible common situation. It seems independent from the size of the tumor or from its metastatic character. The consequences for the management of the patient are major and exceed widely the frame of the nutrition. Undernutrition of patients with cancer is described by a decrease of the energy contributions and a loss of muscular and fat mass, leading to a progressive functional deficiency which can go to the cachectic state. Actually, clinical criteria are proposed allowing to characterize the state of pre-cachexia but it remain too indistinct to allow an early and efficient screening and set up effective measures of prevention of the cachexia, to avoid the loss of muscular tissue and the cast iron of the energy reserves. It is necessary to have clinical and biological markers with diagnostic aim and forecasts during the situations precedents the appearance of cachexia. The present study will allow calibrating a longitudinal study, which could confirm the value of measures made for the diagnosis of pre-cachexia.

Conditions

• Colorectal Tumor

Interventions

Type	Name	Description
PROCEDURE	Biopsy of adipose and muscular tissue
OTHER	Blood sampling
OTHER	Calorimetry
OTHER	Impedance measure	Evaluation of physical composition (non-invasive method)
OTHER	Evaluation of nutritional status	Nutritional status will be assessed by using the "Mini Nutritional Assessment" (MNA) questionnaire and a scale that evaluates anorexia
OTHER	Evaluation of physical performance	This will be assessed by using a "tiredness scale" named "Echelle Visuelle Analogique" (EVA) in french
OTHER	Evaluation of muscular strength	Muscular strength will be assessed thanks to the Handgrip Strength Test and the Short Physical Performance Battery (SPPB)
OTHER	Evaluation of emotional status	The emotional status wil be assessed thanks to the Yesavage Geriatric Depression Scale (GDS)
OTHER	Evaluation of functional status	The functional status will be assessed by using the Activity of Daily Life (ADL) questionnaire and the Instrumental Activities of Daily Living (IADL) Questionnaire

Timeline

• Start date: 2013-10-07
• Primary completion: 2018-02-07
• Completion: 2018-03-07
• First posted: 2014-07-25
• Last updated: 2018-11-23

Locations

1 site across 1 country: France