NCT02199821

Inflammatory Response With Different Lipid Emulsions In Parenteral Nutrition In Children After Bone Marrow Transplantation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Maimónides Biomedical Research Institute of Córdoba · Academic / Other
• Sex: All
• Age: 1 Day – 14 Years
• Healthy volunteers: Not accepted

Summary

Background and Aims: Nutritional support is considered an integral part of the supportive care of bone marrow transplantation patients. Parenteral nutrition emulsions enriched with omega-3 fatty acids can modify the inflammatory response. The aim of this study is to compare plasma cytokines levels in children after bone marrow transplantation using a lipid formula enriched in n-3 FA and other classic soybean oil formula in parenteral nutrition. Methods: A randomized double blinded controlled study including 14 children with BMT and requiring PN for at least 10 days was conducted using a lipid emulsion with fish oil, or soybean oil. Blood samples at baseline, at 10 days and at the end of the PN were taken to analyze plasma interleukins 1 beta, 2, 6, 8, 10 (IL-10) and tumor necrosis factor alpha (TNF-α).

Conditions

• Bone Narrow Transplantation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Formula with soybean oil, medium-chain triglycerides
DIETARY_SUPPLEMENT	Soybean oil formula commonly used in the hospital

Timeline

• Start date: 2011-02-01
• Primary completion: 2013-02-01
• Completion: 2014-02-01
• First posted: 2014-07-25
• Last updated: 2014-07-25