NCT02199275

Effect of General Anesthesia on Enterocyte Damage

Impact of General Anesthesia on Enterocyte Damage

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Besancon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

During non urgent surgery, general anesthesia might induce enterocyte damage. I-FABP is a performant biomarker of enterocyte damage. We aimed to study whether patient ongoing general anesthesia for non-urgent surgery have an elevation of plasma I-FABP concentration.

Detailed description

Inclusion criteria * Indication of non-urgent surgery * General anesthesia protocol using propofol and remifentanyl * One half of the patients have a history of ischemic arteriopathy * One half of the patients have no history of ischemic arteriopathy Exclusion criteria * Age \< 18 years old * Pregnant Primary objective Is there a significant elevation of I-FABP between the pre-anesthesic period and 11 minutes after induction of general anesthesia ? Secondary objectives 1. Is I-FABP elevation higher among patients with history of patent arteriopathy ? 2. Is I-FABP elevation higher among patients presenting with hypotension during anesthesia ?

Conditions

• Non-urgent Surgery
• General Anesthesia

Timeline

• Start date: 2013-08-01
• Primary completion: 2014-08-01
• Completion: 2014-08-01
• First posted: 2014-07-24
• Last updated: 2014-07-24

Locations

1 site across 1 country: France