NCT02198859

Evaluation of Lithium and It's Effect on Clinically Localized Prostate Cancer

Phase 1 Study of Evaluation of Lithium and it's Effect on Clinically Localized Prostate Cancer.

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: University of Kansas Medical Center · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Laboratory testing has suggested that lithium may decrease the incidence of certain types of cancer, including prostate cancer. Additional research has suggested that lithium decreases prostate cancer tumor size over time. This study will investigate the effect of lithium on men with prostate cancer.

Detailed description

As lithium has been shown in an in vitro model to suppress cellular proliferation, and suppress tumor growth in an in vivo xenograft model, we propose to determine its effect on prostate cancer cells in human patients undergoing radical prostatectomy. In this pilot study we plan to assess the toxicity of lithium administration in patients prior to radical prostatectomy. This will include any clinical toxicity as well as any increase in intra-, peri- or postoperative complications.

Conditions

• Prostate Cancer

Interventions

Type	Name	Description
DRUG	Lithium Carbonate

Timeline

• Start date: 2014-04-01
• Primary completion: 2016-08-01
• Completion: 2016-08-01
• First posted: 2014-07-24
• Last updated: 2017-01-09

Locations

1 site across 1 country: United States