NCT02198495

Comparison Study of Two Iron Compounds for Treatment of Anemia in Hemodialysis Patients

Continuous Versus Periodic Intravenous Iron Supplementation in Maintenance Hemodialysis Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 143 (actual)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients with end-stage kidney disease on maintenance hemodialysis frequently require iron supplementation to compensate for ongoing iron losses, and to maintain hemoglobin levels with or without additional use of erythropoiesis-stimulating agents (ESA). The investigators aim to compare two different intravenous iron preparations, ferric carboxymaltose and iron sucrose in 140 hemodialysis patients. The investigators primary objective is to assess whether both agents are equally effective to maintain a target haemoglobin within 10-12 mg/dl. The investigators will also measure ferritin, transferrin, transferrin saturation, and how much ESA therapy is administered. Patients will be randomly assigned to either treatment group and followed in parallel over an active study period of 40 weeks.

Conditions

• Anemia of Chronic Kidney Disease

Interventions

Type	Name	Description
DRUG	Supplementation of ferric carboxymaltose
DRUG	Supplementation of iron sucrose

Timeline

• Start date: 2014-09-01
• Primary completion: 2019-05-01
• Completion: 2019-05-01
• First posted: 2014-07-23
• Last updated: 2020-09-11

Locations

2 sites across 1 country: Austria