NCT02196623

Hypoxia and Exercise in the Elderly

Hypoxia and Aerobic Exercise Interactions in Age-related Metabolic Muscle Dysfunction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 29 (actual)
• Sponsor: Hannover Medical School · Academic / Other
• Sex: All
• Age: 55 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Ageing is the primary risk factor for most chronic diseases including type 2 diabetes mellitus. Sarcopenia and muscular mitochondrial dysfunction with aging are crucial mechanisms leading to decreased exercise tolerance and worsened insulin sensitivity. Thus, metabolic disease and frailty, which limits physical mobility as well as quality of life, share common cellular mechanisms. The investigators will test the hypothesis that a combination of normobaric hypoxia and exercise training elicits a synergistic effect on age-associated metabolic skeletal muscle dysfunction and the investigators will address the molecular mechanisms. In a randomized clinical study, the investigators will compare normoxic and hypoxic training conditions in elderly subjects. Outcome measures will focus on whole body insulin sensitivity and mitochondrial responses in skeletal muscle before and after the 8-week training intervention.

Conditions

• Elderly Persons

Interventions

Type	Name	Description
OTHER	Hypoxic exercise	Supervised, progressive aerobic exercise program for 8 weeks under hypoxic conditions
OTHER	Normoxic Exercise	Supervised, progressive aerobic exercise program for 8 weeks under normoxic conditions

Timeline

• Start date: 2015-06-01
• Primary completion: 2017-09-01
• Completion: 2019-01-01
• First posted: 2014-07-22
• Last updated: 2025-06-29

Locations

1 site across 1 country: Germany