NCT02195726

Efficacy of RIPC to Reduce AKI for Patients Undergoing PCI

The EUROpean and Asian Cardiac and Renal Remote Ischemic Pre-conditioning Study : A Prospective, Randomized Control Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 1,110 (actual)
• Sponsor: A.O.U. Città della Salute e della Scienza · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the present study is to determine if remote ischemic preconditioning reduces incidence of acute kidney injury in patients with reduced kidney function undergoing Percutaneous Coronary Intervention.

Detailed description

Acute kidney injury negatively impacts on prognosis after PCI, and only hydratation have shown to reduce this complication. Remote ischemic preconditioning has been demonstrated to reduce periprocedural MI, while impact on aki remains to be assessed

Conditions

• Acute Kidney Injury

Interventions

Type	Name	Description
PROCEDURE	Remote ischemic preconditioning	four times 5-minute inflations of a blood pressure cuff to 200 mmHg around the upper non dominant arm (or if systolic pressure is more than 150 mmHg, inflation will reach 50 mmHg up per than baseline), followed by 5-minute intervals of reperfusion.
PROCEDURE	Sham remote ischemic preconditioning	In the control group sham preconditioning will be performed with inflation of 10 mmHg more than baseline.

Timeline

• Start date: 2013-01-01
• Primary completion: 2014-07-01
• Completion: 2014-07-01
• First posted: 2014-07-21
• Last updated: 2014-07-21

Locations

7 sites across 3 countries: France, Italy, Spain