NCT02195583

The Effect of Experimental Dentifrices on Remineralization of Caries Lesions In-situ

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 62 (actual)
• Sponsor: GlaxoSmithKline · Industry
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study will evaluate the effect of experimental sodium fluoride-silica dentifrice formulations, with and without zinc, on remineralization of enamel in situ. Following the remineralization phase, the acid resistance of the new mineral formed will be assessed. Fluoride uptake during the remineralization phase will also be measured.

Conditions

• Oral Hygiene

Interventions

Type	Name	Description
DRUG	Sodium fluoride (1426 ppm)	Non-zinc, 1426ppm fluoride as sodium fluoride in a silica gel base
DRUG	Sodium fluoride (1150 ppm)	Non-zinc, 1150ppm fluoride as sodium fluoride in a silica gel base
DRUG	Sodium fluoride (250 ppm)	Non-zinc, 250ppm fluoride as sodium fluoride in a silica gel base
DRUG	Sodium fluoride (1426 ppm) + zinc base A	Zinc base A, 1426ppm fluoride as sodium fluoride in a silica gel base
DRUG	Sodium fluoride (1426 ppm) + zinc base B	Zinc base B, 1426ppm fluoride as sodium fluoride in a silica gel base
DRUG	Fluoride (0 ppm)	Non-zinc, 0ppm fluoride in a silica gel base

Timeline

• Start date: 2014-06-01
• Primary completion: 2014-08-01
• Completion: 2014-08-01
• First posted: 2014-07-21
• Last updated: 2015-05-01
• Results posted: 2015-04-07

Locations

1 site across 1 country: United States