NCT02195388

Focus On Stiffness Reduction, Endothelial Function and Autonomic Nervous System

Phase 1 Study - Focus On Stiffness Reduction, Endothelial Function and Autonomic Nervous System improVement in Patients After MI With or Without hypErtension After Cardiovascular Rehabilitation.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 120 (actual)
• Sponsor: Medical University of Lodz · Academic / Other
• Sex: All
• Age: 20 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Myocardial infarction is related with endothelial function, arterial stiffness and autonomic nervous system dysfunction, but also with arterial hypertension. Hypertension by itself is also related with endothelial function, arterial stiffness and autonomic nervous system dysfunction. Primary aim of study is to investigate how complex cardiac rehabilitation influence endothelial function, arterial stiffness and autonomic nervous system activity according to presence or absence arterial hypertension. Secondary aim is to obtain correlation between methods for the assessment of particular disorders and intercorrelation between different disorders for example endothelial function and autonomic nervous system activity.

Detailed description

We expect that in study groups PWV will improve better that in control group. 5% of the limit value of p \<0.05. We expect that in study groups AASI will improve better that in control group. 5% of the limit value of p \<0.05. We expect that in study groups AI will improve better that in control group. 5% of the limit value of p \<0.05. We expect that time and frequency parameters of HRV will increase in study group. 5% of the limit value of p \<0.05. We expect that parameters of HRT will improve in study group. 5% of the limit value of p \<0.05. We expect improvement in RHI in study group. 5% of the limit value of p \<0.05.

Conditions

• Arterial Stiffness
• Endothelial Function
• Autonomic Nervous System
• Acute Coronary Syndrome
• Arterial Hypertension

Interventions

Type	Name	Description
OTHER	comprehensive cardiac rehabilitation	Standard program of comprehensive cardiac rehabilitation CR with physical activity, behavioral intervention, risk factor modification and intervention.

Timeline

• Start date: 2009-12-01
• Primary completion: 2014-12-01
• Completion: 2015-03-01
• First posted: 2014-07-21
• Last updated: 2017-03-23

Locations

1 site across 1 country: Poland