NCT02193100

Pre and Post Treatment Metabolomic Analysis of Leukemia: A Translational Clinical Trial of the Brown Cancer Center

PRE AND POST TREATMENT METABOLOMIC ANALYSIS OF LEUKEMIA: A Translational Clinical Trial of the Brown Cancer Center

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: University of Louisville · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

To characterize the metabolism of glucose by the leukemic cells in patients with leukemia before and after initial chemotherapy. To compare the metabolism of glucose by leukocytes in healthy volunteers and leukemic cells in leukemic patients.

Detailed description

To characterize glycolytic metabolism in patients as demonstrated in leukemic cells and serum metabolite analysis after C13-glucose administration at strategic time points of treatment. To detect and measure 13C-labeled metabolic markers which may be present in the serum and urine of leukemic patients. To characterize glycolytic metabolism in patients as demonstrated in leukemic cells and serum metabolite analysis after C13-glucose administration at strategic time points of treatment. To detect and measure 13C-labeled metabolic markers which may be present in the serum and urine of leukemic patients.

Conditions

• Leukemia

Timeline

• Start date: 2014-08-01
• Primary completion: 2018-06-01
• Completion: 2019-06-01
• First posted: 2014-07-17
• Last updated: 2017-12-29

Locations

1 site across 1 country: United States