NCT02192723

A Randomized Double-blind Trial With 6 Antipsychotic Drugs for Schizophrenia

Effectiveness of 6 Antipsychotic Drugs in the Treatment of Acute Exacerbations of Chronic Inpatients With Schizophrenia: a Randomized Double-blind Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 550 (actual)
• Sponsor: Beijing HuiLongGuan Hospital · Academic / Other
• Sex: All
• Age: 25 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the efficacy and side effects of 6 commonly used antipsychotic drugs in the treatment of schizophrenia in a Chinese population.

Detailed description

The relative effectiveness of second-generation (atypical) antipsychotic drugs as compared with that of older agents has been incompletely addressed, though newer agents are currently used far more commonly. The investigators compared a first-generation antipsychotic, perphenazine or haloperidol, with several newer drugs in a double-blind study. METHODS: A total of 550 patients with schizophrenia were recruited at 4 Chinese sites and randomly assigned to receive perphenazine (16 to 64 mg per day) or haloperidol(6 t0 20mg per day), olanzapine (5 to 20 mg per day), quetiapine (400 to 750 mg per day), aripiprazole (10 to 30 mg per day) or risperidone (2 to 6.0 mg per day) for up to 8 weeks.

Conditions

• Schizophrenia

Interventions

Type	Name	Description
DRUG	Typical antipsychotic	Haloperidol (6\~20mg/day) and perphenazine (16\~64mg/day), twice per day, 8 weeks
DRUG	Risperidone	2\~6mg/day, twice per day, 8 weeks
DRUG	Olanzapine	Olanzapine, 400\~750mg/day, twice per day, 8 weeks
DRUG	Quetiapine	Quetiapine, 400～750mg/day, twice per day, 8 weeks
DEVICE	Aripiprazole	Aripiprazole, 10～30mg/day, twice per day, 8 weeks
DRUG	Ziprasidone	Ziprasidone 80\~160mg/day, twice per day, 8 weeks

Timeline

• Start date: 2012-06-01
• Primary completion: 2014-06-01
• Completion: 2014-06-01
• First posted: 2014-07-17
• Last updated: 2016-07-12

Locations

1 site across 1 country: China