NCT02189824

Chemotherapy Followed by Infusion of Partially HLA Matched Unrelated Donor Cells for Patients With AML Who Are Ineligible for Stem Cell Transplantation

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: University of Sydney · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

A phase 1 study of infusion of partially HLA matched unrelated donor blood or marrow cells (microtransplantation) following consolidation chemotherapy in patients with AML that are not suitable for allogenic stem cell transplantation.

Detailed description

To determine the safety and tolerability of co-administration of partially HLA antigen matched unrelated donor cryopreserved donor lymphocytes (microtransplantation) with chemotherapy for patients with high risk acute myeloid leukaemia ineligible or unsuitable for high dose chemotherapy and stem cell transplantation.

Conditions

• Acute Myeloid Leukaemia

Interventions

Type	Name	Description
BIOLOGICAL	Partially HLA-matched unrelated donor cells

Timeline

• Start date: 2014-08-01
• Primary completion: 2016-12-01
• First posted: 2014-07-15
• Last updated: 2015-11-02

Locations

1 site across 1 country: Australia