NCT02189122

Comparative Effects of Aspirin and NHP-544C

Comparative Effects of Rapid-Release Aspirin and NHP-544C on Basal and Bradykinin Stimulated Prostacyclin Production

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 61 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The investigators will compare the effects of rapid release aspirin and NHP-544C on the prostacyclin response to intravenous bradykinin.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Bradykinin	Bradykinin will be given intravenously in graded doses. Each dose will be given for 15 minutes.
DRUG	Aspirin 81 mg	Subjects will take Aspirin 81 mg per day for five days.
DRUG	Aspirin 162 mg	Subjects will take aspirin 162 mg per day for 5 days.
DRUG	NHP544-C 81 mg	Subjects will take NHP544C 81 mg per day for five days.
DRUG	NHP544C 162 mg	Subjects will take NHP544C 162 mg once a day for five days.
DRUG	Placebo	Subjects will take matching placebo for five days.

Timeline

• Start date: 2014-07-01
• Primary completion: 2015-07-01
• Completion: 2015-07-01
• First posted: 2014-07-14
• Last updated: 2016-07-12
• Results posted: 2016-06-03

Locations

1 site across 1 country: United States