NCT02184858

Dose Titration of Lisinopril in Children Aged 1 to 18 Years With Primary or Secondary Hypertension

Dose Titration Study to Test Efficacy and Safety of Lisinopril in Children Aged 1 to 18 Years With Primary or Secondary Hypertension.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: University Ghent · Academic / Other
• Sex: All
• Age: 1 Year – 18 Years
• Healthy volunteers: Not accepted

Summary

This open label 4 month study will evaluate efficacy (blood pressure lowering effects) and safety of lisinopril in children 1-18y whose parents grant permission to participate. This dose titration study is being conducted to support the statement that personalized titration of lisinopril (based on blood pressure and renin-aldosterone ratio) can increase patient response.

Conditions

• Primary Hypertension
• Secondary Hypertension

Interventions

Type	Name	Description
DRUG	lisinopril, ACE-inhibitor	Lisinopril 0.1mg/kg/d, titration with + 0.1mg/kg/d. Max; daily dose: 0.4mg/kg. CAVE: dose reduction in case of renal impairment

Timeline

• Start date: 2014-06-25
• Primary completion: 2017-05-08
• Completion: 2018-09-17
• First posted: 2014-07-09
• Last updated: 2018-09-20

Locations

1 site across 1 country: Belgium