NCT02183779

PORH and Response to Cold in Raynaud's Phenomenon.

Rôle Des Acides Epoxy-eicosatriénoïques et du Monoxyde d'Azote Dans l'hyperhémie Post-occlusive cutanée Digitale et la réponse cutanée au Froid Dans le phénomène de Raynaud Primaire

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University Hospital, Grenoble · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The main objective of the study is to determine if implication of epoxy-eicosatriénoïc acids (EETs) and NO during cutaneous post-occlusive hyperemia differs between patients with Raynaud phenomena and healthy volunteers, by studying hyperaemic postocclusive response after microinjection of fluconazole and L-NMMA at the dorsal side of the fingers.

Detailed description

The main objective of the study is to determine if implication of epoxy-eicosatriénoïques acids (EETs) and NO during cutaneous post-occlusive hyperemia differs between patients with Raynaud phenomena and healthy volunteers, by studying hyperaemic postocclusive response after microinjection of fluconazole and L-NMMA at the dorsal side of the fingers. Healthy controls and patients will undergo 3 visits

Conditions

• Raynaud Disease
• Hyperemia
• Cold

Interventions

Type	Name	Description
PROCEDURE	post-occlusive hyperemia
PROCEDURE	cooling box
DRUG	L-NMMA and Fluconazole dermic injection

Timeline

• Start date: 2014-06-01
• Primary completion: 2016-10-01
• Completion: 2017-06-01
• First posted: 2014-07-08
• Last updated: 2015-12-09

Locations

1 site across 1 country: France