NCT02181426

Dose Response of Ketorolac in Knee Arthroscopy

Dose Response of Ketorolac in Out-Patients Undergoing Knee Arthroscopy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 112 (actual)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Ketorolac is administered as current practice to the majority of patients undergoing knee arthroscopy, the appropriate dose of ketorolac to be administered has not been evaluated.

Detailed description

Past studies have examined different doses of ketorolac administered to patients after spinal fusion surgery and found that 7.5 mg every 6 hours was as effective as 15 or 30 mg every 6 hours in decreasing postoperative pain and patient opiate consumption. Since ketorolac side effects such as gastrointestinal and surgical site bleeding seem to be dose related, utilizing a lower dose of ketorolac may be more efficacious.

Conditions

• Meniscectomy

Interventions

Type	Name	Description
DRUG	Ketorolac Dose	Subjects will be assigned an enrollment number. Enrollment numbers will be assigned consecutively in the order of study enrollment. Based on the enrollment number, subjects will be randomized by a pre-determined computer randomization list created by a statistician to receive a ketorolac dose (0, 7.5, 15, 30 mg).

Timeline

• Start date: 2012-03-01
• Primary completion: 2016-12-15
• Completion: 2016-12-15
• First posted: 2014-07-04
• Last updated: 2018-09-21
• Results posted: 2018-06-08

Locations

1 site across 1 country: United States