NCT02180971

Multidetector Coronary CT In Vasospastic Angina

Diagnostic Usefulness of Multidetector Coronary CT in Vasospastic Angina

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Dong-A University · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to compare the extent of coronary vessel stenosis between coronary spasm-induced angina attacks (named vasospastic angina, VSA) patients and health volunteers by multi-detector computed tomography angiography (MDCTA), and to evaluate the diagnostic efficacy of MDCTA in patients with VSA.

Detailed description

Vasospastic angina (VSA) was characterized by transient ischemic ST-segment change during angina attacks. Coronary spasm provocation test, as a diagnostic golden standard, has been widely used for the management of VSA according to JCS 2013 guidelines. With regard to the characteristics of spasm segment, had been clearly described by other invasive imaging methods including intravascular ultrasound and optical coherence tomography. However, there is potential risk during these invasive procedures, such as severe myocardial ischemia or fatal arrhythmia. Presently available imaging test for coronary artery disease including multi-detector computed tomography angiography (MDCTA) with high diagnostic accuracy to evaluate coronary artery stenosis. However, the diagnostic accuracy of MDCTA in patients with VSA is lacking. Therefore, more efficient and safe noninvasive diagnostic method is required for the detection of angina-like attacks patients.

Conditions

• Vasospastic Angina

Interventions

Type	Name	Description
PROCEDURE	Positive CAG with EG test	A positive finding for coronary angiography with an ergonovine provocation test is defined as transient, total, or sub-total occlusion (\>90% stenosis) with signs/symptoms of myocardial ischemia (chest pain and ischemic ECG change).
PROCEDURE	Negative CAG with EG test	Negative test: less than 70% luminal narrowing, without chest pain or ST-segment changes after ergonovine coronary injection

Timeline

• Start date: 2014-04-01
• Primary completion: 2020-12-01
• Completion: 2021-03-01
• First posted: 2014-07-03
• Last updated: 2020-07-22

Locations

1 site across 1 country: South Korea