NCT02180880

Symptom Based Treatment of Neuropathic Pain

Symptom-Based Treatment for Neuropathic Pain in Spinal Cord Injured Patients, Randomized Clinical Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 63 (actual)
• Sponsor: Ju Seok Ryu · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

1\. Neuropathic pain in spinal cord injured patients 1. Inclusion criteria * pain intensity, visual analogue scale \> 3 * a LANSS (Leeds assessment of neuropathic symptoms and signs) score of 12 and above * aged ≥20 2. Method * Stop pain medications * Test oxcarbazepine (150mg twice daily) and pregabalin (150mg twice daily) * Check pain intensity (VAS score) with Baron's classification

Detailed description

In the present study, pharmacologic treatment included pregabalin and oxcarbazepine. Stop medications such as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), tramadol and anti-spastic drugs (baclofen, tizanidine) and other medications known to have effect on pain and the central nervous system prior to the study for at least 3 days. 1. Pain intensity (VAS score) 1. 4 spontaneous characters * electric * burning * pricking * numbness 2. evoked pain * allodynia * heat hyperalgesia * pressure hyperalgesia 2. Location of neuropathic pain 1. neuropathic pain at level of spinal cord injury 2. neuropathic pain below level of spinal cord injury 2\. Side effects

Conditions

• Neuralgia
• Spinal Cord Injury

Interventions

Type	Name	Description
DRUG	Pregabalin and Oxcarbazepine	Subjects will take pregabalin for the duration of 2 weeks. The dosage will be increased from 75 mg twice to 150 mg twice a day. Subjects will stop pregabalin for 1 week and take oxcarbazepine 150mg twice.

Timeline

• Start date: 2012-11-01
• Primary completion: 2014-08-01
• Completion: 2014-08-01
• First posted: 2014-07-03
• Last updated: 2014-08-20

Locations

1 site across 1 country: South Korea