NCT02180425

The Lipid Profile of the Skin Surface in Acne

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 30 (actual)
• Sponsor: University of California, Davis · Academic / Other
• Sex: All
• Age: 12 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate the differences in the skin lipid profile of patients with and without acne. Secondly, the goal is to learn more about what the effects of retinoinds (topical and systemic) are on the the skin lipid profile. We hypothesize that the skin lipid profile of subjects with acne will be lower in inflammatory lipids in comparison to subjects without acne.

Detailed description

Skin lipid profile will be conducted via sebutapes- adhesive tapes that painlessly absorbs sebum from the face. These tapes will be placed on the face for 1 hour. A photograph of the face will be taken during each study visit. A sebumeter will also be used to measure skin sebum secretion rate.

Conditions

• Acne

Interventions

Type	Name	Description
DRUG	Tretinoin or Adapalene	Subjects will apply a pea sized amount of topical retinoid cream once daily at night for 30 days. Subjects will return for a follow-up visit.
DRUG	Isotretinoin	Subjects will take one pill once daily for 5 months. Subjects will return after 1 month and after 4-5 months of treatment for skin lipid profiling.

Timeline

• Start date: 2013-11-01
• Primary completion: 2015-05-01
• Completion: 2015-07-01
• First posted: 2014-07-02
• Last updated: 2017-05-30

Locations

2 sites across 1 country: United States