NCT02179398

Impact of the Lab-score on Antibiotic Prescription Rate in Children With Fever Without Source

Impact of the Lab-score on Antibiotic Prescription Rate in Children Aged 7 Days to 3 Years Old With Fever Without Source.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 278 (actual)
• Sponsor: University Hospital, Geneva · Academic / Other
• Sex: All
• Age: 7 Days – 3 Years
• Healthy volunteers: Not accepted

Summary

Detecting serious bacterial infections (SBI) in children presenting to the Pediatric Emergency Department (PED) with fever without source (FWS) is a frequent diagnostic challenge. The recently described Lab-score, based on the combined determination of Procalcitonin, C-Reactive Protein (CRP) and urine dipstick results, has been shown an accurate tool for SBI prediction on retrospective cohorts. The investigators aimed to assess the usefulness of the Lab-score in safely decreasing unnecessary antibiotic prescriptions in children with FWS, and to prospectively determine the diagnostic characteristics of the Lab-score compared to other classically used SBI biomarkers (white blood cell (WBC) count, band count and CRP).

Conditions

• Fever Without Source

Interventions

Type	Name	Description
BIOLOGICAL	Allocation to the Lab-score group
BIOLOGICAL	Allocation to the control group

Timeline

• Start date: 2010-09-01
• Primary completion: 2013-07-01
• Completion: 2013-07-01
• First posted: 2014-07-01
• Last updated: 2014-10-31
• Results posted: 2014-10-31

Locations

1 site across 1 country: Switzerland