NCT02177708

Quantitative Determination of Brain Water Content in Patients During and After Hepatic Encepalopathy

Quantitative Determination of Brain Water Content in Patients During and After Hepatic Encepalopathy Measured by MR

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 45 (estimated)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

There is increasing evidence that the pathophysiology of hepatic encephalopathy (HE) is tightly associated with low-grade cerebral edema. Uptake of ammonia in astrocytes leads to osmotic swelling caused by glutamine formation. Previous studies were performed in covert HE patients or used indirect methods. Methods: The investigators wish to describes quantitative measurement of localized water content using MRI water mapping in a cohort of patients with cirrhosis during an episode of overt HE type C and again after recovery. Furthermore patients with cirrhosis and no history of HE and healthy subjects will be investigated as controls.

Conditions

• Hepatic Encephalopathy

Timeline

• Start date: 2014-01-01
• Primary completion: 2015-06-01
• Completion: 2015-12-01
• First posted: 2014-06-30
• Last updated: 2014-06-30

Locations

1 site across 1 country: Denmark