NCT02171845

Mechanisms and Factors Responsible for the Inhibition of Transposons During Fetal Gonad Development in Humans

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Centre Hospitalier Universitaire Dijon · Academic / Other
• Sex: Male
• Age: 10 Weeks – 37 Weeks
• Healthy volunteers: Not accepted

Summary

This is a single-centre study over 36 months for the inclusion of 30 patients. The selection and inclusion of patients will take place according to the criterion of Medical Termination of Pregnancy at 4 different gestational ages (8-12 weeks of gestation (WG)), 13-16 WG, 17-23 WG and 25-35 WG. The tissue analysed will principally be the gonads, other somatic tissue will also be systematically harvested in parallel (liver and psoas muscle) for control purposes. The gonads will be subjected to molecular biology analyses destined to quantify the expression of transposons and their inhibitors.

Conditions

• Medical Termination of Pregnancy
• Voluntary Termination of Pregnancy

Interventions

Type	Name	Description
OTHER	surgical biopsies

Timeline

• Start date: 2014-01-29
• Primary completion: 2027-01-01
• Completion: 2027-01-01
• First posted: 2014-06-24
• Last updated: 2022-07-08

Locations

1 site across 1 country: France