NCT02171390

Endothelial Dysfunction, Inflammation and Insulin Resistance in Congenital Hypogonadism and Effect of Testosteron Replacement Therapy

Phase 4 Study That Evaluates the Presence of Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Subjects With Hypogonadotrophic Hypogonadism and Effects of Two Different Testosterone Replacement Regiments on These Parameters.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 130 (actual)
• Sponsor: Gulhane School of Medicine · Academic / Other
• Sex: Male
• Age: 18 Years – 26 Years
• Healthy volunteers: Accepted

Summary

The study searched for answers to two questions 1. Is there endothelial dysfunction, inflammation and insulin resistance in patients with congenital hypogonadotropic hypogonadism? 2. What is the effect of testosterone replacement therapy on endothelial dysfunction, inflammation and insulin resistance?

Conditions

• Hypogonadotrophic Hypogonadism

Interventions

Type	Name	Description
DRUG	Testosterone 250mg injection	The testosterone 250mg ester intramuscular injections performed in three weeks
DRUG	Testosteron 50 mg transdermal gel	50mg testosterone gel implemented on every night

Timeline

• Start date: 2008-08-01
• Primary completion: 2012-06-01
• First posted: 2014-06-24
• Last updated: 2014-06-24

Locations

1 site across 1 country: Turkey (Türkiye)