NCT02169765

HR Versus RFA for Early Stage HCC

Hepatic Resection Versus Radiofrequency Ablation for Early-stage Hepatocellular Carcinoma: a Randomized Controlled Trial

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Guangxi Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Hepatocellular carcinoma (HCC) is the third leading death cancer in the world. It is important to explore a safe and effective therapy for early-stage HCC. Previous studies reported that radiofrequency ablation (RFA) has higher efficacy and is associated with fewer complications and shorter hospital stays than hepatic resection (HR) for early-stage HCC. However, meta-analysis and systematic review found that RFA is associated with higher recurrence rate and lower long-term overall survival.

Conditions

• Hepatocellular Carcinoma
• Liver Cancer

Interventions

Type	Name	Description
OTHER	Hepatic resection	Adequate remnant liver volume was 30% for HCC patients without cirrhosis, and \>50% for HCC patients with chronic hepatitis, cirrhosis, or severe fatty liver.
OTHER	Radiofrequency ablation	Radiofrequency ablation is performed in less than one week after clinical diagnosis.

Timeline

• Start date: 2020-08-01
• Primary completion: 2022-12-20
• Completion: 2022-12-30
• First posted: 2014-06-23
• Last updated: 2020-07-22

Locations

1 site across 1 country: China