NCT02167204

18F-FLT PET/CT in Measuring Cell Proliferation in Patients With Brain Tumors

Cellular Proliferation Imaging Using [18F] Fluorothymidine (FLT) Positron Emission Tomography (PET) in Brain Tumors

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: University of Washington · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This pilot clinical trial studies fluorine F 18 fluorothymidine (FLT) positron emission tomography (PET)/computed tomography (CT) in measuring cell proliferation in patients with brain tumors. Comparing results of diagnostic procedures done before, during, and after treatment may help doctors measure tumor growth and plan the best treatment.

Detailed description

PRIMARY OBJECTIVES: I. Using FLT PET/CT as a measure of cellular proliferation, assess tissue proliferation in disease sites of brain tumor patients before therapy (surgery, chemotherapy or radiotherapy or any combination of these). II. Determine level of change in cellular proliferation compared with baseline (scan 1) in brain tumors at mid-therapy (scan 2), after completion of therapy (scan 3) and in the clinical follow-up period (scan 4), when possible. III. Correlate levels of cellular proliferation measured by FLT PET/CT at baseline and treatment-induced changes in brain tumor proliferation with clinical response status (clinical categories are complete remission, lesser degrees of response/stable disease, and no response). SECONDARY OBJECTIVES: I. Assess spatial heterogeneity of FLT uptake to identify local differences in brain tumor disease burden. OUTLINE: Patients undergo 18F-FLT PET/CT at baseline (pre-therapy), mid-therapy, completion of therapy, and 1 year after completion of therapy or time of suspected recurrence. After completion of study, patients are followed for up to 7 years.

Conditions

• Metastatic Malignant Neoplasm in the Brain
• Primary Brain Neoplasm
• Recurrent Brain Neoplasm

Interventions

Type	Name	Description
PROCEDURE	Computed Tomography	Undergo 18F-FLT PET/CT
RADIATION	Fluorothymidine F-18	Undergo 18F-FLT PET/CT
PROCEDURE	Positron Emission Tomography	Undergo 18F-FLT PET/CT

Timeline

• Start date: 2012-11-01
• Primary completion: 2019-01-21
• Completion: 2019-01-21
• First posted: 2014-06-18
• Last updated: 2020-01-13
• Results posted: 2020-01-13

Locations

1 site across 1 country: United States