NCT02164422

Does Guanfacine Attenuate Stress-Induced Drinking?

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Evaluating the effect of guanfacine on alcohol consumption. The investigators hypothesize that guanfacine versus placebo will decrease the amount of alcohol consumption (mls consumed) during the 2-hour self-administration period across two laboratory sessions.

Conditions

• Alcohol Drinking

Interventions

Type	Name	Description
DRUG	Guanfacine 3mg/day	3 mg/day Guanfacine with 3-week lead-in period. Maintained at steady state throughout lab sessions. After lab sessions, given taper supply of medication. Follow up 2 weeks after completion of taper.
DRUG	Guanfacine 1.5mg/day	1.5 mg/day Guanfacine with 3-week lead-in period. Maintained at steady state throughout lab sessions. After lab sessions, given taper supply of medication. Follow up 2 weeks after completion of taper.
DRUG	Placebo

Timeline

• Start date: 2014-06-01
• Primary completion: 2020-03-31
• Completion: 2020-03-31
• First posted: 2014-06-16
• Last updated: 2021-07-08
• Results posted: 2021-04-21

Locations

1 site across 1 country: United States