NCT02156245

Evaluation of the Effects of Eccentric Training on a Cycle Ergometer, Versus Conventional Concentric Training

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 212 (actual)
• Sponsor: Centre Hospitalier Universitaire Dijon · Academic / Other
• Sex: All
• Age: 40 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to assess the efficacy of a rehabilitation protocol based on individualized combined eccentric and concentric cycle ergometer training compared to classical concentric cycle training among patients with either coronary artery disease (CAD) or chronic obstructive pulmonary disease (COPD). This study will therefore evaluate the efficacy of combined eccentric/concentric training on physical capacity and overall autonomy, and will analyse the adaptive mechanisms with regard to both adaptation to cardiac and muscular effort and tolerance.

Detailed description

The research will take place in 3 phases: PHASE 1 : 30 healthy volunteers will be included to test tolerance to personalized exercise on an eccentric cycle ergometer. PHASE 2 : 15 patients suffering from coronary artery disease (CAD) and 15 patients suffering from chronic obstructive pulmonary disease (COPD) will be included to test the same protocol. PHASE 3 : A total of 169 patients split into 2 parallel groups will be included: a group receiving conventional rehabilitation (group A) and the other group receiving eccentric exercise combined to conventional rehabilitation (group B). Coronary patients: 93 patients will be included (62 patients in group A and 31 in group B). COPD patients: 76 patients will be included (38 patients per group).

Conditions

• Readaptation to Effort
• Coronaropathy
• Chronic Obstructive Pulmonary Disease

Interventions

Type	Name	Description
OTHER	conventional rehabilitation program (including concentric cycle ergometer)
OTHER	cycling included into a conventional rehabilitation program

Timeline

• Start date: 2013-09-16
• Primary completion: 2019-04-03
• Completion: 2019-04-03
• First posted: 2014-06-05
• Last updated: 2019-07-22

Locations

2 sites across 1 country: France