NCT02155049

Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues

Phase 3 Study of Treatment of Soft Tissue Expansion and Exophthalmos in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues.

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Rabin Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Prostaglandin analogues eye drops are common and effective treatment for decreasing Intra-Ocular Pressure (IOP) in Glaucoma patients. A number of recently published case reports have documented periorbital fat atrophy following treatment by prostaglandin analogues. In this study the investigators want to use this side-effect of prostaglandin analogues for the treatment of orbital and periocular fat proliferation in inactive Thyroid eye disease (TED) patients, as a conservative substitute for surgical intervention.

Conditions

• Thyroid Associated Ophthalmopathies

Interventions

Type	Name	Description
DRUG	bimatoprost 0.03%	The patients will receive a single daily drop of bimatoprost for six months.

Timeline

• Start date: 2014-11-01
• Primary completion: 2017-05-01
• Completion: 2017-05-01
• First posted: 2014-06-04
• Last updated: 2018-02-19

Locations

1 site across 1 country: Israel