NCT02152358

PTH - Preemptive Treatment for Herpesviridae

Efficacy of a Preemptive Treatment by Ganciclovir or by Aciclovir in ICU Patients Requiring Prolonged Mechanical Ventilation and Presenting a Viral Replication (CMV and/or HSV) - Prospective, Randomized, Double-blinded Multicenter Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 317 (actual)
• Sponsor: Assistance Publique Hopitaux De Marseille · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to show that a preemptive treatment by ganciclovir (for positive CMV viremia) or aciclovir (for positive HSV oro-pharyngeal PCR) is able to increase the number of ventilator-free days at Day 60.

Conditions

• Viral Pneumonia

Interventions

Type	Name	Description
DRUG	Aciclovir	Intravenous 15 mg/kg/d during 14 days
DRUG	Ganciclovir	intravenous 10 mg/kg/d for 14 days
DRUG	Placebo

Timeline

• Start date: 2014-02-05
• Primary completion: 2018-04-21
• Completion: 2023-04-05
• First posted: 2014-06-02
• Last updated: 2023-04-06

Locations

1 site across 1 country: France