NCT02152098

Skeletal Muscle Strain Injuries and the Connective Tissue: Characterization, Recovery and Optimal Treatment

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 85 (actual)
• Sponsor: Bispebjerg Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Firstly, the investigators aim to study the biochemical, structural and functional changes associated with acute muscle strain injury in the acute phase and during rehabilitation in vivo. Specific factors present after the injury and their effects on connective tissue cells will be examined in vitro. Secondly, the investigators will investigate individuals with chronic pain, scar tissue and inferior function after a previous muscle strain injury and test a specific rehabilitation program to alleviate pain and disabilities associated with the preceding muscle injury. The investigators have the following hypotheses: 1. Humoral growth factors and pro-inflammatory macrophages released into the injured area post strain injury stimulate formation of connective tissue in vitro. 2. Early onset of rehabilitation will be superior to a delayed start of rehabilitation for the healing process, in regards to structural improvement of tissue and better clinical function. 3. Scar tissue following a muscle strain injury is characterized by disorganized structure of connective tissue. 4. Mechanical loading in the form of heavy eccentric muscle activity for 12 weeks will lead to a local re-modeling of scar tissue, and result in improved function and reduced symptoms in patients with chronic pain and impaired function after a previous muscle injury.

Conditions

• Muscle Strain

Interventions

Type	Name	Description
PROCEDURE	Acute Early onset of rehabilitation	Early onset of rehabilitation
PROCEDURE	Acute Delayed onset of rehabilitation	Delayed onset of rehabilitation
PROCEDURE	Chronic Exercise	Exercise
PROCEDURE	Chronic Control	Control

Timeline

• Start date: 2014-04-01
• Primary completion: 2016-12-01
• Completion: 2017-03-01
• First posted: 2014-06-02
• Last updated: 2017-07-26

Locations

1 site across 1 country: Denmark