NCT02150694

Local Haemodynamic Effects of Apelin Agonists and Antagonists in Man in Vivo

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: University of Cambridge · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Apelins are substances which occur naturally in the body, and have an important role in heart disease. They have been shown to make blood vessels dilate, and improve the way the heart works. The investigators have devised 2 sets of experiments to investigate how the apelins affect blood vessels. In the first group of experiments,the investigators will give healthy volunteers up to 3 different apelin substances, and use special research techniques to see how they affect the way that blood vessels work in the forearm. In the second group of experiments, the apelins will be given along with another form of apelin which blocks the effects of apelin in laboratory experiments. The investigators want to see if it blocks the effects of apelin in healthy humans. The investigators intend to test the hypothesis that: Apelin agonists are vasodilators in human resistance vessels, this effect will be blocked by an apelin receptor antagonist. This study will help us to understand more about how apelins work, and to suggest how they might be used to treat heart disease.

Conditions

• Cardiovascular Disease

Interventions

Type	Name	Description
PROCEDURE	Forearm venous occlusion plethysmography	Forearm venous occlusion plethysmography to study to measure forearm blood flow during intra-arterial infusion of the apelin peptides.
PROCEDURE	Aellig hand vein technique	Hand vein measurements will be used to assess the response to apelin peptides and apelin receptor blocker in the human hand vein vascular bed.
OTHER	Apelin agonist infusion	Escalating doses of apelin (1/10/100nmol/min) will be administered.
OTHER	Apelin receptor antagonist infusion	Dose finding study (range 1-300nmol/min) and co-infusion study with apelin peptides

Timeline

• Start date: 2012-01-01
• Primary completion: 2013-08-01
• Completion: 2013-08-01
• First posted: 2014-05-30
• Last updated: 2014-05-30

Locations

1 site across 1 country: United Kingdom