NCT02148692

Protective Ventilation With Higher Versus Lower PEEP During General Anesthesia for Surgery in Obese Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 2,013 (actual)
• Sponsor: Technische Universität Dresden · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Postoperative respiratory failure, particularly after surgery under general anesthesia, adds to the morbidity and mortality of surgical patients. Anesthesiologists inconsistently use positive end-expiratory pressure (PEEP) and recruitment maneuvers in the hope that this may improve oxygenation and protect against postoperative pulmonary complications (PPCs), especially in obese patients. While anesthesiologists tend to use PEEP higher than in non-obese patients. While it is uncertain whether a strategy that uses higher levels of PEEP with recruitment maneuvers truly prevents PPCs in these patients, use of higher levels of PEEP with recruitment maneuvers could compromise intra-operative hemodynamics. The investigators aim to compare a ventilation strategy using higher levels of PEEP with recruitment maneuvers with one using lower levels of PEEP without recruitment maneuvers in obese patients at an intermediate-to-high risk for PPCs. We hypothesize that an intra-operative ventilation strategy using higher levels of PEEP and recruitment maneuvers, as compared to ventilation with lower levels of PEEP without recruitment maneuvers, prevents PPCs in obese patients at an intermediate-to-high risk for PPC.

Conditions

• Morbid Obesity
• Surgery
• General Anesthesia

Interventions

Type	Name	Description
PROCEDURE	Higher PEEP
PROCEDURE	Lower PEEP

Timeline

• Start date: 2014-07-01
• Primary completion: 2018-02-01
• Completion: 2018-05-01
• First posted: 2014-05-28
• Last updated: 2019-01-03

Locations

24 sites across 16 countries: United States, Austria, Belgium, Brazil, Canada, France, Germany, Hungary, Israel, Italy, Netherlands, Spain, Sweden, Switzerland, Turkey (Türkiye), United Kingdom