Trials / Unknown
UnknownNCT02148562
Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity
Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity With Next-generation Sequencing: From Chronic Infection to End-stage Liver Disease and Liver Cancer
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 274 (estimated)
- Sponsor
- Universitaire Ziekenhuizen KU Leuven · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
In this project proposal, the investigators will investigate the genetic alterations of Hepatitis B Virus (HBV) strains circulating in Belgian patients who developed end stage liver disease. Additionally, the investigators will compare and link these data sets with three genetic factors involved in immune system response.
Detailed description
This project proposes to identify and characterize the genetic alterations associated with intra-host evolution of HBV from a chronically infection status to an end-stage liver disease status.
Conditions
Timeline
- Start date
- 2014-04-01
- Primary completion
- 2017-12-01
- Completion
- 2017-12-01
- First posted
- 2014-05-28
- Last updated
- 2014-05-28
Locations
1 site across 1 country: Belgium
Source: ClinicalTrials.gov record NCT02148562. Inclusion in this directory is not an endorsement.